Tiziana Life Sciences: Expanding the pipeline, unlocking value
Tiziana Life Sciences PLC (LON:TILS, NASDAQ:TLSA) has expanded the range of indications — which include severe inflammatory and autoimmune diseases — of its lead therapy fully human anti-CD3 monoclonal antibody Foralumab, signing a new collaboration in Brazil to develop the nasal formulation of Foralumab to treat respiratory failure in COVID-19 patients. Nasally administered Foralumab would offer a first in class immunotherapeutic approach, designed to strengthen immune defence and to directly address the primary site of inflammation, i.e. the nasal passage and respiratory tract. The acceleration of the demerger and listing plans for the genomics risk assessment business including StemPrintER and SPARE, set for completion in 2020, can help unlock very buoyant commercial prospects, and crystallise the value of both the therapeutic and genomics arms of the business.
Tiziana has expanded the pipeline of indications for the nasal formulation of Foralumab, its fully human anti-CD3 monoclonal antibody (mAb), having signed an agreement to cover collaboration between its team of scientists at the Harvard Medical School and those at the Santa Casa de Misericórdia de Santos hospital in Sao Paulo, to conduct a clinical study to investigate the mAb for treating respiratory failure in COVID-19 patients. The clinical study will include patients, treated either with nasally administered Foralumab alone, or combined with the orally-administered antiviral drug dexamethasone, and is scheduled to start imminently, with clinical data anticipated to be reported by the end of 2020.
Quick facts: Tiziana Life Sciences PLC
Price: 142.78 GBX
Market Cap: £276.3 m
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