Revive Therapeutics: Initiation report
Revive Therapeutics (CSE:RVV, OTCQB:RVVTF) is a speciality life sciences company focussed on repurposing drugs for rare and infectious diseases. The company has a pipeline comprising three main platforms:
Bucillamine for treatment of infectious diseases including COVID-19:
Bucillamine (BUC) is a medication with a well-established safety profile having been prescribed for arthritis for more than 30 years. Revive Therapeutics has been working with BUC for five years as a repurposing opportunity and has obtained two Food and Drug Administration (FDA) INDs (investigational new drug applications) with BUC to treat gout flares and cystinuria. During 2020 the company has made an IND filing concerning the use of BUC to treat COVID-19 with intellectual property around infectious diseases.
BUC has shown significant potential to reduce lung inflammation damage associated with a serious infection, and could, therefore, reduce fatalities from COVID-19. The company received a recommendation from the FDA that it skip Phase 2 trials and make an application to move immediately to Phase 3. If this trial proceeds and begins to deliver results, we believe this would be a major catalyst for the share price. We examine this opportunity on p3-5.
Revive is targeting rare diseases, mental health and addiction using formulations based on psilocybin, a psychedelic compound derived from fungi. The development of pharmaceuticals from psychedelics has become a growth field in recent years attracting interest from big pharma as well as smaller specialists. Revive Therapeutics has a robust portfolio of formulations and collaborations in place with leading research partners such as the University of Wisconsin.
CBD for autoimmune hepatitis:
Revive is developing a therapy for autoimmune hepatitis (AIH) based on cannabidiol (CBD). The company has obtained Orphan Drug status for this treatment.
Quick facts: Revive Therapeutics
Price: 0.185 CAD
Market Cap: $30.33 m
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